Cysteinoyl- and Cysteine-containing Dipeptidoylbenzotriazoles with Free Sulfhydryl Groups: Easy Access to N-terminal and Internal Cysteine Peptides
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چکیده
منابع مشابه
REVIEW Synaptic Cysteine Sulfhydryl Groups as Targets of Electrophilic Neurotoxicants
Many structurally diverse chemicals (e.g., acrylamide, 2,4dithiobiuret, methylmercury) are electrophiles and cause synaptic dysfunction by unknown mechanisms. The purpose of this Forum review is to discuss the possibility that highly nucleophilic cysteine thiolate groups within catalytic triads of synaptic proteins represent specific and necessary targets for electrophilic neurotoxicants. Most ...
متن کاملSynaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.
Many structurally diverse chemicals (e.g., acrylamide, 2,4-dithiobiuret, methylmercury) are electrophiles and cause synaptic dysfunction by unknown mechanisms. The purpose of this Forum review is to discuss the possibility that highly nucleophilic cysteine thiolate groups within catalytic triads of synaptic proteins represent specific and necessary targets for electrophilic neurotoxicants. Most...
متن کاملOn the Reversible Reaction of Cyanate with Sulfhydryl Groups and the Determination of Nh2-terminal Cysteine and Cystine in Proteins.
The present paper is a continuation of studies on the reaction of cyanate with amino acids, peptides, and proteins (1). In the earlier report, emphasis was placed on the speed of the reaction of cyanate with the sulfhydryl groups of cysteine, glutathione, and urea-denatured P-lactoglobulin. The work to be presented in this communication is concerned primarily with a study of the cyanate-sulfhyd...
متن کاملOn the Reversible Reaction of Cyanate with Sulfhydryl Groups and the Determination of NH,-terminal Cysteine and Cystine in Proteins*
The present paper is a continuation of studies on the reaction of cyanate with amino acids, peptides, and proteins (1). In the earlier report, emphasis was placed on the speed of the reaction of cyanate with the sulfhydryl groups of cysteine, glutathione, and urea-denatured P-lactoglobulin. The work to be presented in this communication is concerned primarily with a study of the cyanate-sulfhyd...
متن کاملAlkylation of cysteine-containing peptides to mimic palmitoylation.
Numerous proteins that are involved in cell signaling and viral replication require post-translational modification by palmitoylation to function properly. The molecular details by which this palmitoyl modification affects protein function remain poorly understood. To facilitate in vitro biochemical and structural studies of the role of palmitoylation on protein function, a method was developed...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2012
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2011.01303.x